Strong science and AI

Our AGI® prediction model

Our proprietary model relies on artificial intelligence and uses validated sets of big data. It predicts the inflammatory status (AGI®) based on selected inflammatory biomarkers, and the subsequently delivered tips are customized to help fight the personal inflammaging process.

Global Scientific evidence

Thousands of publications linking low-grade chronic inflammation to ill-health already published.

Acute inflammation is necessary

Our body reacts to harmful stimuli, such as microbes, damaged cells or irritants with the process of an acute inflammation. This is a protective response and aims at restoring the healthy state. It is necessary for survival and followed by an anti-inflammatory response.

Medzhitov. Nature 2008; 454:428–35

But chronic inflammation harms

The low-grade chronic inflammation shares a common ground with acute inflammation. However, it does not present with the traditional signs of acute inflammation such as redness, heat or pain nor is it followed by an anti-inflammatory response. This persistent low-grade chronic inflammation is the common soil underlying the myriad of chronic diseases such as diabetes, cancer, cardiovascular or Alzheimer’s diseases.

Liu et al. Front.Hum.Neurosci. 2017; 11:316

Organic vegetables. Healthy food. Fresh organic carrots in farmers hands

Nutrition

What we eat has a strong impact on the low-grade chronic inflammation. This has been verified across the world and it is now established that a bad food choice increases the risk of such an inflammation.

Custodero et al. Ageing Res.Rev. 2018; 46:42–59; Shivappa et al. Public Health Nutr. 2014; 17:1689–96

Movement

Sufficient regular physical activity has a tremendous impact on health. While previously it was thought that each movement episode triggers an inflammatory response, research has now clarified that in the long-term the contrary is the case. Regular movement induces anti-inflammatory effects and is linked to a reduced low-grade chronic inflammation.

Handschin, Spiegelman. Nature 2008, 454:463–9; Pedersen. J.Physiol. 2009; 587:5559–68

Young man diving into a lake. Careless and risky water jump. Summer vacation dangerous outdoor activity. Side view.
Backpacker Camping Trekking Wanderlust Leisure Concept

Cognition

The brain and the immune system continuously interact with each other. Low-grade chronic inflammation does not, therefore, spare the brain or its proper functioning, and is associated with brain aging and cognitive impairments. Fortunately, brain aging and cognitive functioning can be positively influenced by physical or cognitive activities exerting anti-inflammatory effects.

Ligthart et al. Am.J.Hum.Genet. 2018; 103:691–706; Malarkey et al. Brain Behav.Immun. 2013; 27:145–54

Environment

Environmental aspects such as air pollution can strongly increase the pro-inflammatory status. Along with the other inflammaging factors they do contribute to the premature aging process and, thus, their identification and prevention has the potential to lead to a longer and healthier life.

Bai et al. Environ.Res. 2017; 158:366–72.; Viehmann et al. Occup.Environ.Med. 2015; 72:656–63
Water spring with sky reflection in summer Carpathian mountains. Landscape photography

Inflammatory biomarkers

The acute-phase reactant C-reactive protein (CRP) is one of the most consistently measured and reliable biomarker indicating the presence of low-grade chronic inflammation. Other inflammatory biomarkers include blood cellular markers (e.g. total leucocytes, granulocytes and activated monocytes) and soluble mediators (cytokines and chemokines (TNF-α, interleukin (IL)-1, IL-6, IL-8, CC chemokine ligand 2 (CCL2), CCL3, CCL5)), adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin), adipokines (adiponectin) and other acute-phase proteins (serum amyloid A, fibrinogen).

Antonelli, Kushner. FASEB J. 2017, 31:1787–91; Pearson et al. Circulation 2003, 107:499–511; Ridker. J.Am.Coll.Cardiol. 2016, 67:712–23. Minihane et al. Br.J.Nutr. 2015; 114:999–1012

Aging

The general theories of aging consider an imbalance between stressors of diverse origins and the concomitant loss of the capacity to compensate for them, as the driver resulting in a physical and cognitive decline, ultimately leading to death. The chronic pro-inflammatory state is a major player in this context creating the state of inflammaging and a high susceptibility to disability, diseases and premature death.

Fulop et al. Semin.Immunol. 2018; 40:17–35; Ferrucci, Fabbri. Nat.Rev.Cardiol. 2018; 15:505–22

The World Health Organization
only targets world problems

Among their major topics, next to climate change, one finds many risk factors like unhealthy diets and physical inactivity that lead to low-grade chronic inflammation and premature aging

Inflammaging accelerates
the aging process

The continuous exposure to low-grade chronic inflammation creates the state of inflammaging resulting in a high susceptibility to disability, diseases and premature death

Ferrucci, Fabbri. Nat.Rev.Cardiol. 2018; 15:505–22

Source: TIME

“The secret killer”

Low-grade chronic inflammation is considered “clinically silent” as it does not present the signs of an acute inflammation such as redness, heat, swelling and pain.

Time magazine named it, therefore, the secret killer.